Brain structural abnormalities in six major psychiatric disorders: shared variation and network perspectives

Shared genetics among major psychiatric disorders.

Since 2005, the National Human Genome Research Institute database of published genome-wide association studies (GWAS) has accumulated more than 5110 entries for over 500 traits. The rapid growth of data repositories has enabled researchers to undertake large studies and meta-analyses, and has increased the power for detection of trait-associated variants. In The Lancet, the Psychiatric Genomics...

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, an...

Neuroleptics in progressive structural brain abnormalities in psychiatric illness.

Structural brain abnormalities in multiple sclerosis patients with major depression.

OBJECTIVE To assess the association between major depression and structural brain abnormalities in patients with multiple sclerosis (MS). METHODS Two groups of patients with clinically definite MS were studied: 21 with Diagnostic and Statistical Manual of Mental Disorders (4th ed.)-defined major depression and 19 without. The groups did not differ on demographic, disease, or cognitive measure...

Psychiatric disorders in children and adolescents in the first six months after mild traumatic brain injury.

The objective was to assess the nature, rate, predictive factors, and neurocognitive correlates of novel psychiatric disorders (NPD) after mild traumatic brain injury (MTBI). Children age 5-14 years with MTBI (N=87) from consecutive admissions to five trauma centers were enrolled and studied with semistructured psychiatric interviews soon after injury (baseline), and 70 of these children were a...